Objective To compare the management systems of food disinfectants in countries and regions， including the European Union， the United States and China， by analyzing the similarities and differences in their management models for food disinfectants， and provide evidence for improving safety management practices of food disinfectants in China.Methods Relevant laws， regulations， standards， and other documents related to food disinfectants were collected from different countries/regions， and then the similarities and differences of the regulatory entities， disinfection targets， approval of main ingredients， and other compliance requirements of food disinfectants， were sorted out and analyzed.Results The management approaches for disinfectants with varying intended uses differ slightly among the European Union， the United States， and China， however， they all mandate the food disinfectants to be strictly used according to product labels or instructions. China’s regulations restrict the use of food disinfectants to surface disinfection of raw fruits， raw vegetables， and poultry carcasses during the slaughter process， while the United States and the European Union allow their uses for various types of food such as fruits， vegetables， carcass of livestock and poultry， and seafood. In terms of raw material management， the European Union only requires approval for active ingredients， while the United States and China have established corresponding approval processes for both active and auxiliary ingredients.Conclusion It is recommended to enhance the safety management system of food disinfectants in China， evaluate the effectiveness of food disinfectants in multiple scenarios， intensify targeted trainings for relevant standards， and strengthen process oversight to foster the healthy and sustainable growth of the industry.