Objective To investigate and analyze two mushroom poisoning incidents in Cangzhou City, identify the causative mushroom species, and summarize key findings to provide references for clinical diagnosis, treatment, and prevention of similar incidents. Methods? The two incidents were investigated using descriptive epidemiological methods. The mushroom species were identified through morphological and molecular biological analyses, followed by comprehensive assessment. Results? A total of 8 patients were identified across both incidents. Primary clinical manifestations included neurological symptoms such as dizziness, blurred vision, hallucinations, confusion, numbness, and weakness. The clinical course lasted 4–5 days. All patients recovered and were discharged with no fatalities. Morphological and molecular biological identification confirmed the mushrooms involved in both incidents asPanaeolus cyanescens.Conclusion ?This case marks the first reported incident of mycetism caused by accidental ingestion of Panaeolus cyanescens in Hebei Province. Enhanced public education, surveillance, early warning systems, and training of grassroots medical personnel are crucial to prevent similar incidents and improve clinical management.