Objective To establish an ultra high performance liquid chromatography tandem mass spectrometry method for determination of 6 alternaria toxins in peanuts by solid phase purification column purification.Methods The sample was extracted with acetonitrile-water-formic acid， purified through solid phase purification columns. Using a mobile phase of methanol-1.0 mmol/L ammonium bicarbonate solution， a HSS T3 column for separation， and ESI- mode for detection， and determined by UPLC-MS/MS， with internal standard quantification.Results The six types of alternaria toxins showed good linear relationships within their respective determination ranges （all r values were greater than 0.999）， the detection limit of this method were in the range of 0.02 to 0.23 μg/kg， the relative standard deviation was less than 3.5%， and the recoveries were 87.4%-117.7%.Conclusion This method is simple， fast， has good purification effects， high sensitivity， and good reproducibility， making it suitable for the rapid detection of residues of six types of alternaria toxins in peanuts simultaneously.