In recent years， as a renewable resource， the development and utilization of plant-based ingredients have become an important emerging force in the development of the food industry. The safety assessment of ingredients involves the utilization of environmental resources and food safety. This paper briefly summarizes and analyzes the common issues in the application materials for the safety assessment of novel food ingredients from plants， introducing the key points that need to be focused on when submitting the application materials， in order to provide reference for scientific and effective evaluation materials for application enterprises.