Objective To analyze the epidemiological characteristics of microbial foodborne disease outbreaks in Guizhou Province from 2011 to 2022 and provide basis and support for the prevention and control of microbial foodborne diseases.Methods The outbreaks of microbial foodborne diseases reported in Guizhou Province from 2011 to 2022 were summarized and conducted descriptive analysis.Results A total of 64 outbreaks of microbial foodborne diseases were reported in Guizhou Province from 2011 to 2022 Leading to 1 613 illnesses and 5 death， with the case fatality rate of 0.31%；the outbreaks of microbial foodborne diseases were mainly concentrated in May， June， July and September； all cities and prefectures have reported， Guiyang City， Anshun City reported the most outbreaks； poisoning places mainly occur in the home and school； the main pathogenic factors were Staphylococcus aureus and its toxin， Bacillus cereus and Salmonella； the main implicated food were grain products， multiple or complex food， meat and meat products.Conclusion The number of microbial foodborne disease outbreaks reported in Guizhou Province is small， but the number of cases is large. It is necessary to enhance the capacity of grassroots disease control institutions in Guizhou Province to handle food safety incidents and improve the identification rate of pathogenic factors； strengthen the publicity and education of microbial foodborne diseases to reduce the occurrence of microbial foodborne disease outbreaks.