Objective To construct a set of scientific and comprehensive food safety evaluation models for assessing the overall situation of regional food safety.Methods The food safety evaluation index system was established by considering environmental factors， public satisfaction， food safety supervision， and other influencing factors， and the combination weights were assigned to each index by using the combination weighting method， and the approximate ideal solution method was used to analyze the overall situation of regional food safety based on the data of multiple indexes.Results It was determined that the food safety evaluation index system includes 5 primary indicators and 14 secondary indicators， including population and economic status， environmental status， food safety supervision， food consumption safety， and social satisfaction. Using the statistical data related to the evaluative sampling of food safety in A Province in 2021 for empirical evidence， a comprehensive evaluation of the food safety status in 21 prefecture-level cities in A Province was carried out.Conclusion The model constructs the evaluation index system from multiple perspectives and levels and sets the weights of the indexes in a scientific way， which makes the food safety evaluation index system more comprehensive， further enhances the credibility of the evaluation results， and provides a new path for exploring the comprehensive evaluation of the food safety situation.