陕西省市售谷物中4种交链孢毒素的监测及暴露风险评估
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作者单位:

陕西省疾病预防控制中心,陕西 西安 710054

作者简介:

赵迪 女 助理研究员 研究方向为食品理化检验 E-mail:254181360@qq.com

通讯作者:

张路钱 男 主管医师 研究方向为传染病预防与控制 E-mail:245209492@qq.com

中图分类号:

R155

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The monitoring and exposure assessment of 4 kinds of alternaria toxins in grains on sale in Shaanxi Province
Author:
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Shaanxi Provincial Centre for Disease Control and Prevention, Shaanxi Xi’an 710054, China

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    摘要:

    目的 了解陕西省市售谷物中4种交链孢毒素的污染情况,评估居民膳食交链孢毒素暴露量引起的健康风险。方法 2022年在流通环节随机采集小麦粉、玉米粉(糁)、大米共171份,采用超高效液相色谱质谱法测定4种交链孢毒素的含量,结合第五次中国总膳食研究中陕西省的食物消费量调查数据,采用毒理学关注阈值(TTC)方法评估谷物中交链孢毒素的膳食暴露风险。结果 陕西省谷物中交链孢酚、交链孢酚单甲醚、细交链孢菌酮酸和腾毒素的平均值为0.128、0.461、15.3和1.67 μg/kg。小麦粉中细交链孢菌酮酸和腾毒素含量具有显著的相关性。谷物中交链孢酚的均值膳食暴露量为0.64 ng/(kg·BW·d),低于TTC值。谷物中交链孢酚的P97.5膳食暴露量为4.62 ng/(kg·BW·d),超TTC值。谷物中交链孢酚单甲醚的均值、P97.5膳食暴露量分别为3.45和17.8 ng/(kg·BW·d),超TTC值。谷物中细交链孢菌酮酸的均值、P97.5膳食暴露量分别为144和336 ng/(kg·BW·d),低于TTC值。谷物中腾毒素的均值、P97.5膳食暴露量分别为16.7和32.6 ng/(kg·BW·d),低于TTC值。结论 陕西省市售谷物中4种交链孢毒素均有不同程度污染。陕西居民谷物中交链孢酚和交链孢酚单甲醚膳食暴露量较高,2~7岁儿童是暴露量较高人群;细交链孢菌酮酸和腾毒素膳食暴露风险较低。

    Abstract:

    Objective To investigate the contamination of 4 kinds of alternaria toxins in grains in Shaanxi Province and evaluate the risk to the health of dietary exposure.Methods A total of 171 samples of wheat flour, rice and corn grits were randomly collected in circulation in 2022. Four kinds of alternaria toxins were determined by ultra high performance liquid chromatography tandem mass spectrometry. The health risk of altemaria toxins in grains were evaluated based on the threshold of toxicological concern method.Results The average contents of alternariol, alternariol monomethyl ether, tenuazonic acid and tentoxin were 0.128, 0.461, 15.3 and 1.67 μg/kg in grains, with the detection rates of 8.19, 56.73, 57.31 and 38.01%, respectively. There was a significant correlation between tenuazonic acid and tentoxin contents in wheat flour. The alternariol average dietary exposure is 0.64 ng/(kg·BW·d), below the corresponding TTC values. The alternariol P97.5 dietary exposure is 4.62 ng/(kg·BW·d), above the corresponding TTC values. The alternariol monomethyl ether average and P97.5 dietary exposures are 3.45 and 17.8 ng/(kg·BW·d), above the corresponding TTC values. The tenuazonic acid average and P97.5 dietary exposures are 144 and 336 ng/(kg·BW·d), below the corresponding TTC values. The tentoxin average and P97.5 dietary exposures are 16.7 and 32.6 ng/(kg·BW·d), below the corresponding TTC values.Conclusion The grains were contaminated by 4 kinds of alternaria toxins to different degrees in Shaanxi Province. The dietary exposure levels of alternariol and alternariol monomethyl ether in grains exceed the TTC values, and children aged from 2 to 7 years old were higher exposure. Tenuazonic acid and tentoxin were lower dietary exposure.

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赵迪,袁文婷,乔海鸥,张路钱.陕西省市售谷物中4种交链孢毒素的监测及暴露风险评估[J].中国食品卫生杂志,2024,36(11):1252-1257.

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  • 收稿日期:2024-01-03
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  • 在线发布日期: 2025-03-14
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