Objective Assess the exposure levels and health risks of DON and acetylated derivatives from grains and their products in Ji’nan.Methods Two hundred and four grains samples in 2022 were collected，the acute toxicity risk and chronic toxicity risk of DON group dietary exposure were evaluated by point evaluation and probability evaluation methods for different age and gender groups in Ji’nan.Results The point assessment shows that there is no significant acute intake risk among Ji’nan populations at the highest pollution levels of DON and acetylated derivatives， but about 10% high pollution levels of grains and products pose chronic risks to health. The probability assessment results indicate that the median level of DON group exposure is 0.096-0.228 μg/（kg·BW·d）. And 3.11%-10.74% population has higher exposure levels than PMTDI， high-risk group is the younger age group. The DON content in wheat flour and products is the main risk factor for DON group dietary exposure， with a contribution rate from 93.8% to 98.0%.Conclusion The overall risk of DON group dietary exposure among Ji’nan populations is relatively low， but the younger age group is a high-risk group and should be taken seriously.