Objective A method for determination of acrylamide in Xinjiang specialty foods （naan products， rice dumplings， roasted buns and oil incense） by solid phase extraction combined with ultra-high performance liquid chromatography-tandem mass spectrometry was established.Methods Using water-acetonitrile as the extraction solvent and n-hexane as the degreasing solvent， the sample was extracted by vortex oscillation. After centrifugation， remove the layer solution and purify it through MCX solid phase extraction column. The purified liquid was concentrated by nitrogen blowing and measured after resolvation with pure water. Water-methanol was used as the mobile phase for gradient elution， ACQUITY UPLC HSS T3 （100 mm×2.1 mm， 1.8 μm） column separation， and tandem mass spectrometry isotope internal standard method for qualitative quantification.Results The method has good linearity in the range of 1.0-200 ng/mL （r²=0.999 5）. Among the four foods， the standard recovery rate of the three concentration levels were 89.5%-99.4%， and the relative standard deviation （n=6） were 1.8%-6.4%.Conclusion This method has low consumption of solvent extraction， easy operation， good purification effect， accurate results， which is suitable for the determination of acrylamide in Xinjiang specialty foods.