Objective To understand the serotype， drug resistance status， and homology of Salmonella in the food poisoning incident， and provide scientific basis for investigating and tracing the source of the food poisoning incident.Methods Real time fluorescent quantitative PCR was used for serotyping of Salmonella from diarrhea patients in food poisoning events， their common dining environment and food samples， micro broth dilution method was used for drug sensitivity test， pulsed field gel electrophoresis test and whole genome sequencing for homology analysis.Results Twelve strains of Salmonella were successfully isolated and cultured （including 2 food samples， 1 kitchen utensil sample and feces from 9 patients）， which were identified as Salmonella enterica by serum typing. All 12 strains of Salmonella enterica were multidrug-resistant strains， with the predominant resistance being STR-AMP-AMS-NAL-CIP-CT； The homology of 12 strains of Salmonella enteritidis is greater than 80%.Conclusion The Salmonella enterica that caused the food poisoning in this case are all multidrug-resistant， and the Salmonella enterica from food， kitchen utensils and patients have a high degree of homology， indicating that the food poisoning incident was caused by this food.