Objective To provide reference for the development of microbial foodborne disease prevention and control strategies， the epidemiological characteristics and spatial aggregation of microbial foodborne disease outbreaks in Guangdong Province from 2011 to 2020 were analyzed.Methods Descriptive analysis was conducted on the outbreak information of microbial foodborne diseases in Guangdong Province from 2011 to 2020. Arcgis 10.8 software was used to analyze the incidence and spatial aggregation.Results From 2011 to 2020， a total of 613 outbreaks of microbial foodborne diseases were reported in Guangdong Province， with a total of 10 716 cases， a total incidence of 9.30/100 000， a total hospitalization rate of 22.14%， and a fatality rate of 0.07%. Cases were mainly concentrated in the Pearl River Delta region， with the highest number of outbreaks reported in 2019， and mainly in the third quarter. The main sources of food were hotels and restaurants （200 cases）， workplace canteens （153 cases） and families （88 cases）. Meat and meat products were the main culprits （141 cases）. Vibrio parahaemolyticus， Salmonella and Staphylococcus aureus were the main pathogenic factors， causing 182， 172 and 85 outbreaks of foodborne diseases， respectively. Improper processing was the main cause of outbreaks， causing 254 foodborne disease outbreaks.The outbreaks of microbial foodborne diseases in Guangdong Province showed regional clustering， and the hot spots were mainly concentrated in Zhuhai City， Zhongshan City， Dongguan City and Shenzhen City.Conclusion Microorganisms foodborne disease outbreaks in Guangdong Province mainly in the Pearl River Delta region of Guangdong Province， Relevant places should emphasis intervention， strengthen the health education of chefs such as key crowd. Specification should be used to minimize microorganisms foodborne disease outbreak occurs.