Objective: retrospective analysis of specific Immunoglobulin E (sIgE) antibody test results for seven inhalant allergens and seven food allergens in children from Hebei Province to guide allergy management. Methods: sIgE test from 23,904 children (0-14 years) at a Hebei hospital (2016-2019) was conducted using the immunoblotting method. The influence of allergen number, grade, age, season, and gender was statistically analyzed. Results: 61.76% of the total patients reacted to at least on allergens, whereas most children reacted to 1-2 allergens. Male patients showed higher positivity for inhalant allergens and food allergens. Inhalant allergen positivity rate increased with age, while food allergens peaked in early childhood. Higher positivity rates for inhalant allergens were seen in summer and autumn, while positivity rates for food allergens fluctuate over time. Conclusion: Allergen positivity rates vary significantly by allergen type, grade, gender, age, and season. This study analyzes key factors to develop tailored diagnostic and management strategies that enhance allergy care and reduce healthcare burdens.