栀子食用人群栀子苷暴露评估
作者:
作者单位:

1.湖南农业大学,湖南 长沙 410125;2.国家食品安全风险评估中心,国家卫生健康委员会食品安全风险评估重点实验室,中国医学科学食品安全创新单元,北京 100022;3.中国中医科学院中药研究所中药质量控制技术国家工程实验室,北京 100022;4.丹东市振安区疾病预防控制中心,辽宁 丹东 118003

作者简介:

邱雪娇 女 在读硕士生 研究方向为公共卫生与预防医学 E-mail:1104254484@qq.com

通讯作者:

覃思 男 教授 研究方向为食品营养基因组学 E-mail:qinsiman@hunau.cn
包汇慧 女 研究员 研究方向为免疫学 E-mail:baohuihui@cfsa.net.cn

中图分类号:

R155

基金项目:


Exposure assessment of geniposide in Gardenia consuming population
Author:
Affiliation:

1.Hu’nan Agricultural University,Hu’nan Changsha 410125, China;2.China National Center for Food Safety Risk Assessment, Chinese Academy of Medical Sciences, NHC Key Laborarory of Food Safety Risk Assessment, Beijing 100022, China;3.National Engineering Laboratory of Chinese Medicine Quality Control Technology, Institute of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine, Beijing 100022, China;4.Dandong Zhen’an District Center for Disease Control and Prevention, Liaoning Dandong 118003, China

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    摘要:

    目的 了解我国居民栀子食用情况,评估我国栀子食用人群栀子苷暴露水平及健康风险。方法 通过文献检索和专项监测收集我国栀子中栀子苷含量数据,结合2019—2022年我国食药物质消费量调查数据,采用简单分布方法和概率评估方法获得我国不同人群通过食用栀子的栀子苷暴露水平及健康风险。结果 我国9省栀子食用率为10.32%,每日食用量均值为0.36 g,高消费人群每日栀子食用量为1.48 g。简单分布评估显示,9省栀子食用人群的栀子苷每日平均暴露量为0.29 mg/kg·BW,高消费人群(P95)栀子苷暴露量为1.28 mg/kg·BW,9省栀子食用人群中有17.20%的居民通过食用栀子的栀子苷暴露量超过其每日可耐受摄入量(TDI,0.386 mg/kg·BW)。河南省食用人群每日平均暴露量最高,为0.54 mg/kg·BW。概率评估结果显示,我国14.70%的栀子食用人群栀子苷暴露量超过TDI,具有潜在健康风险。结论 我国栀子食用人群的栀子苷暴露风险总体较低,但部分高消费人群(P95)存在健康风险。

    Abstract:

    Objective To understand the situation of Gardenia consumption in Chinese residents and to assess the geniposide exposure level and health risk of the Gardenia consumption population in China.Methods Data on geniposide content in Gardenia jasminoides in China were collected through literature search and special monitoring, incorporating data from the 2019-2022 survey on consumption of food and drug substances in China, and the simple distribution method and probability assessment method were used to obtain the geniposide exposure level and health risk of different populations in China through the consumption of Gardenia jasminoides.Results The consumption rate of gardenia in 9 provinces of China was 10.32%, and the mean value of consumption was 0.36 g,and daily Geniposide consumption of 1.48 g for high consumers Simple distribution assessment showed that the mean exposure of geniposide of the edible population of Gardenia in 9 provinces was 0.29 mg/kg·BW, Exposure to geniposide in high consumers (P95) was 1.28 mg/kg·BW, Among the Gardenia consuming population in 9 provinces, 17.20% of the residents were exposed to geniposide through Gardenia consumption exceeding their tolerable daily intake (TDI, 0.386 mg/kg·BW) of Gardenia glycosides. The daily average exposure of the edible population in He’nan Province was the highest 0.54 mg/kg·BW. The results of the probabilistic assessment showed that 14.70 % of the Gardenia consuming population in China had geniposide exposure exceeding the TDI, posing a potential health risk.Conclusion The risk of exposure to geniposide in China’s Gardenia consuming population is generally low, but there is a health risk in some high consuming population (P95).

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邱雪娇,李强,张磊,潘峰,李建文,范鹏辉,王智民,包汇慧,覃思.栀子食用人群栀子苷暴露评估[J].中国食品卫生杂志,2024,36(4):398-406.

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  • 收稿日期:2024-01-03
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  • 在线发布日期: 2024-07-04
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