上海市市售婴幼儿配方乳粉中氯丙醇酯和缩水甘油酯的监测及膳食暴露评估
作者:
作者单位:

上海市市场监督管理局信息应用研究中心(上海市食品安全技术应用中心),上海 200233

作者简介:

宇盛好 男 工程师 研究方向为食品安全风险监测与评估 E-mail:yushenghao@smda.sh.cn

通讯作者:

彭少杰 男 主任医师 研究方向为食品安全风险监测与评估 E-mail:pengshaojie2008@qq.com

中图分类号:

R155

基金项目:

2022年度上海市市场监督管理局科技项目(2022-67)


Monitoring and dietary exposure assessment of chloropropanol esters and glycidyl esters in infant formula sold in Shanghai City
Author:
Affiliation:

Information Application Research Center of Shanghai Municipal Administration for Market Regulation (Shanghai Food Safety Technology Application Center), Shanghai 200233, China

Fund Project:

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    摘要:

    目的 了解上海市市售婴幼儿配方乳粉中氯丙醇酯(MCPDE)和缩水甘油酯(GE)的污染水平,评估婴幼儿膳食暴露风险。方法 利用2020年上海市市售90件婴幼儿配方乳粉中MCPDE和GE的风险监测数据,结合婴幼儿膳食消费量数据,采用点评估法对婴幼儿经婴幼儿配方乳粉的3-MCPDE、2-MCPDE和GE进行膳食暴露评估。结果 上海市市售婴幼儿配方乳粉中3-MCPDE、2-MCPDE和GE的检出率分别为100%、100%和12.2%,含量平均值分别为0.084、0.021和0.005 mg/kg,最大值分别为0.231、0.034和0.031 mg/kg。上海市0~6月龄婴儿每日经婴幼儿配方乳粉摄入3-MCPDE的平均暴露量和P95暴露量分别为1.262和2.166 μg/kg·BW,分别占3-MCPDE每日耐受摄入量(TDI,2 μg/kg·BW)的63.1%和108.3%。6~12、12~36月龄婴幼儿每日经婴幼儿配方乳粉摄入3-MCPDE的平均暴露量和P95暴露量均低于TDI值。不同月龄组婴幼儿每日经婴幼儿配方乳粉摄入2-MCPDE的平均暴露量为0.118~0.319 μg/kg·BW。不同月龄组婴幼儿每日经婴幼儿配方乳粉摄入GE的平均暴露边界比(MOE)和P95 MOE均大于10 000。结论 上海市0~36月龄婴幼儿每日经婴幼儿配方乳粉摄入3-MCPDE和GE的健康风险总体上处于可接受水平。但对于高食物消费量的0~6月龄婴儿,其通过婴幼儿配方乳粉暴露3-MCPDE的健康风险需引起关注。

    Abstract:

    Objective We aimed to evaluate the dietary exposure risk to infants by investigating the chloropropanol ester (MCPDE) and glycidyl ester (GE) contamination levels in infant formula sold in Shanghai City.Methods The dietary exposure of 3-MCPDE, 2-MCPDE, and GE for infants through infant formula was assessed by the point assessment method according to the risk monitoring data of MCPDE and GE in 90 infant formula sold in Shanghai City in 2020 and the dietary consumption data of infants.Results The detection rates of 3-MCPDE, 2-MCPDE, and GE in infant formula sold in Shanghai City were 100%, 100%, and 12.2%, respectively. The mean contents were 0.084, 0.021, and 0.005 mg/kg, and the maximum values were 0.231, 0.034, and 0.031 mg/kg, respectively. The mean and 95 percentile values of daily 3-MCPDE intake of infants aged 0-6 months in Shanghai City through infant formula were 1.262 and 2.166 μg/kg·BW, accounting for 63.1% and 108.3% of the tolerable daily intake (TDI) of 3-MCPDE (2 μg/kg·BW), respectively. The mean and 95 percentile value of daily 3-MCPDE exposure of infants aged 6-12 and 12-36 months through infant formula were lower than the TDI value. The mean value of daily 2-MCPDE exposure of infants in different month-age groups through infant formula were 0.118-0.319 μg/kg·BW. The margin of exposure values of mean and 95 percentile of daily GE exposure of infants in different month-age groups through infant formula were greater than 10 000.Conclusion For infants and young children aged 0-36 months in Shanghai City, the health risks of daily intake of 3-MCPDE and GE through infant formula were generally at an acceptable level. However, for infants aged 0-6 months with high food consumption, the health risk of exposure to 3-MCPDE through infant formula merits further evaluation.

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宇盛好,李亦奇,张露菁,彭少杰.上海市市售婴幼儿配方乳粉中氯丙醇酯和缩水甘油酯的监测及膳食暴露评估[J].中国食品卫生杂志,2023,35(11):1605-1611.

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  • 收稿日期:2022-10-18
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