Objective To understand the predominant multi-locus sequence typing types， their temporal and spatial distribution characteristics， and epidemic trends of Salmonella isolated from patients with foodborne diseases in Jiangxi Province， the corresponding relation between the serotypes and sequence types （STs） was analyzed.Methods Three hundred and thirteen isolates from patients with foodborne diseases from 2014 to 2018 in Jiangxi Province were used as the research subjects. Multi-locus sequence typing was used to genotype the strains. The relation between the spatial and temporal distribution characteristics of the STs and serotypes was analyzed.Results The 313 isolates were divided into 39 STs. The dominant STs were ST34 （32.59%）， ST11 （15.97%）， and ST19 （11.50%）. The most common ST types annually were ST34， ST11， and ST19. There were regional differences in the distribution of STs. Shangrao had the most STs （20）， followed by Fuzhou （15） and Jingdezhen （14）. The dominant STs in Nanchang， Xinyu， and Yingtan were ST11， ST19， and ST19， respectively， whereas the dominant ST type in the other cities was ST34. The 313 Salmonella isolates were classified into 30 serotypes. The dominant serotypes were S. serovars 4［5］，12：i：- （30.35%）， S. enteritidis （15.97%）， and S. typhimurium （14.06%）.Conclusion Many STs of Salmonella strains， but mainly ST34， ST11， and ST19， were isolated from patients with foodborne diseases in Jiangxi Province. The three dominant STs were distributed in different regions of Jiangxi Province， but there were also individual differences in the temporal and spatial distribution of the STs.