嘉兴市疾病预防控制中心，浙江 嘉兴 314050
葛淼华 男 副主任技师 研究方向为理化检验 E-mail：firstname.lastname@example.org
吴小琼 女 副主任技师 研究方向为理化检验 E-mail：email@example.com
Jiaxing Center for Disease Control and Prevention, Zhejiang Jiaxing 314050, China
目的 了解嘉兴市经营环节海产品中砷的形态分布情况，评估食用海产品暴露的砷对人体的健康风险。方法 采用液相色谱-电感耦合等离子体质谱联用技术（HPLC-ICP-MS）对嘉兴市经营环节中采集的5种共105份海产品样品总砷及砷形态污染情况进行检测，结合嘉兴市居民水产品消费数据，对食用海产品带来的无机砷暴露的健康风险进行分析。结果 105份样品中，5种海产品中总砷平均含量范围为0.85~41.85 mg/kg，主要以无毒的砷甜菜碱或砷糖为主，有机砷含量占总砷的90%以上。无机砷的检出率为45.7%，检出浓度范围为0.015~1.169 mg/kg，中位值为0.011 mg/kg，含量较高的海产品主要为海藻类、甲壳类，其中1份样品高于GB 2762—2022的水产品限量值，超标率为0.95%。暴露边界比值（MOE）健康风险分析结果表明，嘉兴市居民食用海产品的健康风险较低（MOE值均远大于1），城市居民风险程度略高于农村居民，女性风险程度略高于男性。结论 嘉兴市居民食用一般海产品暴露的无机砷引起的健康风险较低，但要避免长期大量摄入无机砷较高的海产品（海藻类、甲壳类）。
Objective To understand the speciation of arsenic in seafood sold in Jiaxing City， the health risks of arsenic exposure due to seafood consumption were evaluated.Methods Total arsenic levels and arsenic speciation in 105 samples collected from five seafood categories were detected by high-performance liquid chromatography inductively coupled plasma mass spectrometry. The health risks of inorganic arsenic exposure caused by edible seafood were analyzed based on data for the consumption of aquatic products.Results After testing 105 samples， the average total arsenic content in the five major types of seafood ranged from 0.85 to 41.85 mg/kg. However， it was primarily in the form of nontoxic arsenobetaine or arsenosugars， with organic arsenic accounting for more than 90% of the total arsenic content. The detection rate of inorganic arsenic was 45.7%， with concentrations ranging from 0.008 to 1.169 mg/kg， and a median value of 0.011 mg/kg. Seafood products with the highest levels of arsenic were mainly seaweed and crustaceans， and one sample exceeded the maximum limit set by the National Food Safety standard GB 2762—2017 for water products by 0.95%. The results of the margin of exposure health risk analysis indicated that the health risks associated with consuming seafood for residents of Jiaxing City were relatively low （margin of exposure values significantly higher than 1）. The risk level was slightly higher for urban residents than for rural residents and slightly higher for females than for males. Increased seafood consumption increased the risk level. Considering factors， such as overall dietary exposure， cooking methods， and transformation during consumption， the risk level would further increase.Conclusion The health risk caused by inorganic arsenic exposure in seafood is relatively low， but long-term intake of seafood （seaweed and chitin） with high inorganic arsenic content should be avoided.