Objective This study aimed to analyze the medication rules of health food with Cassiae Semen as the main raw material.Methods A database of health food containing Cassiae Semen was established. The functional ingredients of the health food were counted， of which the nature， taste， meridian tropism， and categories were described. The Apriori algorithm， Kulc， and IR were used to analyze the association rules.Results A total of 316 health foods were accounted for， including 102 items for weight loss， 81 items for laxatives， 76 items for assisting in lowering blood lipid， and 22 items for relieving visual fatigue， comprising 89% （281/316）. Among the health foods for weight loss， the most widely used raw materials were Cassiae Semen， followed by Nelumbinis Folium and Crataegi Fructus. The representative drug combinations were Cassiae Semen- Poria - Alismatis Rhizoma and Cassiae Semen- Alismatis Rhizoma - Nelumbinis Folium. In laxative health food， the most widely used raw materials were Cassiae Semen， followed by Crataegi Fructus， Aloe， and green tea. The representative drug combinations included Cassiae Semen-Green Tea-Sennae Folium. Among the auxiliary hypolipidemic health foods， the most widely used raw materials were Cassiae Semen， Crataegi Fructus， and Nelumbinis Folium. The representative drug combinations were Cassiae Semen - Notoginseng Radix et Rhizoma - Salvia Miltiorrhiza Radix et Rhizoma and Cassiae Semen- Nelumbinis Folium - Crataegi Fructus. Among the health foods for relieving visual fatigue， the most widely used raw materials were Cassiae Semen， Lycii Fructus， and Chrysanthemi Flos. The representative drug combinations included Cassiae Semen- Lycii Fructus - Chrysanthemi Flos.Conclusion The main functions of Cassiae Semen used in health food were weight loss， laxative， auxiliary blood lipid-lowering， and relief of visual fatigue. The medication rules were consistent with the theory of traditional Chinese medicine.