Objective To provide reference data for the prevention， control， and treatment of Vibrio parahaemolyticus infection， the dominant band type of pulsed field gel electrophoresis （PFGE）， drug resistance， and virulence gene present in V. parahaemolyticus detected during foodborne disease surveillance cases in Tongzhou district， Beijing， from 2015 to 2021 was investigated.Methods V. parahaemolyticus was isolated and cultured from stool samples of outpatient diarrhea cases in designated monitoring hospitals in Tongzhou district from 2015 to 2021. Serotyping， virulence gene detection， PFGE cluster analysis， and drug sensitivity tests were performed.Results The detection rate of V. parahaemolyticus in 2 828 fecal samples was 3.54%， and the peak months of detection were from July to September every year. A statistically significant difference in the detection rate of V. parahaemolyticus in different years （χ²=53.94， P<0.001） was observed. Among the 100 strains of V. parahaemolyticus， one strain did not carry the tlh gene， and 89.00% of the strains carried the pathogenic virulence genes tdh. The dominant serotype of V. parahaemolyticus was O3∶K6 （66/100）， followed by O4∶K8 （9/100）. The results of PFGE typing showed that V. parahaemolyticus had 39 band types named V1-V39， the band similarity was between 79.6% and 100%， and the gene distribution was highly polymorphic. V22 and V25 were the dominant band types of V. parahaemolyticus in Tongzhou district. The resistance rate of strains to cefazolin was the highest （32.00%）， followed by that to ampicillin （14.00%） and polymyxin E （13.00%）， and sensitivity to all the other four types of drugs was 100%.Conclusion V. parahaemolyticus detected in foodborne disease surveillance cases in Tongzhou district from 2015 to 2021 was O3∶K6 type tdh⁺- trh^- strain， which is resistant to cefazolin， ampicillin， and polymyxin E. The similarity of the main epidemic strains in the PFGE pattern is more than 93.1%， and there is an outbreak risk. Food safety departments need to thoroughly monitor V. parahaemolyticus and issue outbreak warnings to prevent foodborne disease outbreaks.