Objective To analyze the epidemiological characteristics of Salmonella infection in Wenzhou City from 2006 to 2021 and provide a scientific basis for the prevention and control of Salmonella infection.Methods Salmonella was identified and serotyped， and the epidemiological and etiological characteristics were analyzed.Results From 2006 to 2021， 1 232 strains of Salmonella were isolated from 42 300 cases of diarrhea caused by foodborne diseases in Wenzhou City， with a total isolation rate of 2.91%， covering 90 serotypes （14 flora）， of which the floras were mainly O： 4（B）， O： 9（D1）， O： 3，10（E1）， O： 8（C2-C3）， and O： 7 （C1）； Salmonella typhimurium， Salmonella enteritidis， Salmonella London， and Salmonella derby were the main serotypes； 18-60 years old， over 61 years old and under 2 years old infants were the main infection group； Salmonella was susceptible mainly in spring， summer and autumn with obvious seasonality and the peak period of detection of foodborne Salmonella was from May to November.Conclusion Salmonella infection in Wenzhou City has obvious epidemiological characteristics in terms of seasonal and population distribution； therefore， we should continue to strengthen the surveillance of food-borne diseases， and further improve the ability of early identification， early warning， prevention， and control of hidden dangers in food safety.