Objective To analyze the spatial and temporal characteristics and clustering distribution of foodborne diseases in Guangdong Province from 2016 to 2018， and provide evidence for the development of prevention and control strategies.Methods The cases of foodborne diseases in Guangdong Province from 2016 to 2018 were extracted from the National Foodborne Surveillance and Reporting System. The epidemiological characteristics of the cases were analyzed， and ArcGIS 10.8 software was applied to display the spatial autocorrelation analysis of cases.Results From 2016 to 2018， a total of 76 943 cases of foodborne diseases were reported in Guangdong Province， with a male to female ratio of 1.16∶1. The most common occupational population was scattered children （26.58%， 20 452/76 943）， and the number of cases in 0-5 years old group was the largest （23 584 cases， 30.65%）， 29 072 cases were sampled and tested， and the overall positive detection rate of pathogenic bacteria was 17.03% （4 950/29 072）. The positive rate of Salmonella was 14.84% （4 314/29 072）. The positive rate of Vibrio parahaemolyticus was 1.29% （374/29 072）. The positive rate of diarrheagenic Escherichia coli was 0.83% （241/29 072）. The positive rate of Shigella was 0.07% （21/29 072）. The overall positive rate of norovirus was 0.83% （241/29 072）. Mixed food accounted for the largest proportion of suspected source disease exposure（21.69%）， and the main place of eating was at home （65.53%）. The annual incidence of foodborne diseases in 2016—2018 generally showed two peaks： one peak was in August and the other one was from October to December. Spatial analysis showed that the incidence of foodborne diseases had a certain spatial clustering from 2016 to 2018.Conclusion The incidence of foodborne diseases was low in Guangdong Province from 2016 to 2018. Salmonella was the main pathogen detected， mainly concentrated in the 0-5 years old age group， and the peak of incidence was concentrated in August， October to December. The occupation distribution was mainly scattered children， and diarrhea was the main symptom. The suspected food was mainly mixed food， and the eating place was mainly family. The incidence of foodborne diseases in Guangdong Province has obvious spatial and temporal clustering， and the prevention and control of foodborne diseases should be strengthened.