Objective To analyze the serotype characteristics， epidemiological characteristics and trend of antibiotic resistance of reported cases of Salmonella in Wuxi City， Jiangsu Province from 2017 to 2020.Methods Two hundred and sixteen Salmonella strains isolated from specimens of diarrhea cases （inpatient and outpatient） in Wuxi Foodborne Disease Sentinel Surveillance Hospital from 2017 to 2020 were collected， and the serotype identification and analysis of 216 strains were performed by the slide agglutination method. A micro broth dilution method was used to detect the drug susceptibility of Salmonella to 13 kinds of antibiotics.Results The 216 strains of Salmonella were divided into 42 serotypes. There were two dominant serotypes. Sixty two cases of Salmonella enteritidis accounted for 28.70%， and 57 cases of Salmonella typhimurium accounted for 26.39%. The results of drug resistance analysis showed that 216 strains of Salmonella were highly sensitive to meropenem， amikacin， azithromycin and ceftazidime， and the proportion of highly sensitive strains was higher than 90%； all Salmonella had the highest resistance rate to ampicillin， reaching 68.06%. The resistance rate to meropenem was the lowest， only 0.46%. The resistance rate of Salmonella to ampicillin increased year by year from 2017 to 2020， and resistance to ampicillinthe was the highest each year. A total of 130 strains had developed multi-drug resistance （60.19%）. The spectrum with the largest number of drug-resistant strains was AMP-TET-STR， accounting for 5.56% （12/216）， and the dominant drug resistance spectrum was not obvious.Conclusion The prevalent serotypes of Salmonella in Wuxi City were mainly enteritidis and typhimurium， and the drug resistance of Salmonella was severe. An efficient control mechanism should be established as soon as possible， drug sensitivity monitoring should be strengthened， treatment plans should be optimized， and antibiotic abuse should be avoided.