Objective Analyze Through the collation and analysis of the surveillance data of foodborne diseases in Guiyang City from 2015 to 2019, in order to understand the characteristics and regularity of foodborne diseases in the region. Methods The surveillance data were statistically analyzed according to the time of onset, age, occupation, place of occurrence,food packaging mode and regional distribution. Results A total of 4 335 cases of foodborne diseases were reported in Guiyang surveillance hospital from 2015 to 2019. The period from June to October is the high incidence period of foodborne diseases, which accounts for 59.22% (2 567/4 335) of the total reported cases.Infant and farmers are high-risk groups of foodborne diseases, mainly aged 0-3 years and 18-59 years old, accounting for 71.79% (3 112/4 335). The main place of occurrence was family, accounting for 67.14% (2 785/4 148), followed by catering service institutions. Most of the food processing and packaging method were home-made, accounting for 48.29% (2 006/4 154), and mixed food accounted for 34.11% (1 417/4 154). The second was fungi and their products 25.16% (1 045/4 154). The top three districts of high reported cases in Guiyang were Nanming, Huaxi and Yunyan, total accounting for 50.77% (2 201/4 335). Conclusion The season of high incidence of foodborne diseases in Guiyang was in hot seasons, and families and food service organizations were the high-risk places. Food safety supervision and health education should be further targeted to prevent and control the occurrence and prevalence of food-borne diseases.