Objective To analyze the outbreaks causing by gelsemine in Guangxi in 2015-2017 and provide a scientific basis for the prevention and control of gelsemine poisoning. Methods The monitoring data of gelsemine poisoning of Guangxi in 2015-2017 was collect, and the causes, suspicious food, clinical characteristics, treatment method were analyzed. Results During 2015 and 2017,7 people were exposed, 21 were attacked and 10 were dead with the fatality rate of 47.6%, the mean incubation period was 30 minutes. In the case distribution, men accounted for 61.9% (13/21), 50-60 years old accounted for 47.6% (10/21). Nonlocal people accounted for 71.4% (15/21), and migrant workers accounted for 61.9% (13/21). The main clinical symptoms were dizziness and blurred vision (100.0%, 21/21). All the roots, pollen and leaves of the gelsemine plants were poisonous during the exposure. The self-brewing wine with gelsemine got the highest fatality rate (77.8%, 7/9). Conclusion There were different ways of gelsemine poisoning. Nonlocal people (migrant workers) were more likely to suffer from gelsemine plants. Health education should be strengthened to improve the awareness of prevention.