Objective To summarize and analyze the molecular typing and drug resistance trends of Salmonella Derby(S.Derby)in Sichuan Province during the past 10 years from 2007 to 2016, so as to understand the contamination status of S.Derby in Sichuan, and provide reference data for outbreak warning, traceability investigation and antibiotic use strategy. Methods Using pulse field gel electrophoresis(PFGE)and micro broth dilution to test the molecular typing and susceptibility of 14 antibiotics for 106 strains of S.Derby from Sichuan Province from 2007 to 2016, which were isolated from clinical patients, food practitioners, food poisoning outbreaks, breeding animal and retail food. Results Result showed that 106 strains of S.Derby had different levels of resistance to 14 kinds of antibiotics. The resistance rates of human and animal source strains to tetracycline, nalidixic acid, chloramphenicol and compound sulfonamide were all above 20%. The resistance rates of human source strains to cefotaxime, ciprofloxacin, ampicillin, ampicillin/sulbactam and cefazolin were higher than those of animal source. The resistance rates of animal source strains to tetracycline, nalidixic acid and chloramphenicol was higher than that of human source. A total of 106 strains of S.Derby were divided into 67 PFGE patterns by digestion with Xba I. The clinical patients food practitioners and retail raw pork isolates from different years had the same PFGE pattern. Conclusion The situation of drug resistance of S.Derby isolates in Sichuan was rather serious with an increasing trend. PFGE types were diverse. The clinical patients food practitioners and retail raw pork isolates from different years had the same PFGE pattern.