食品中遗传毒性致癌物风险评估方法研究
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(国家食品安全风险评估中心,北京 100022)

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肖潇 男 助理研究员 研究方向为食品安全风险评估E-mail:xiaoxiao@cfsa.net.cn通信作者:┣┣(中)通信作者┫┫隋海霞 女 研究员 研究方向为食品安全风险评估E-mail:suihaixia@cfsa.net.cn

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中国食品科学技术学会食品科技基金—雅培食品营养与安全专项科研基金(2017-17)


Study on risk assessment approaches of genotoxic carcinogens in food
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(China National Center for Food Safety Risk Assessment, Beijing 100022, China)

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    摘要:

    目的 研究目前国际上食品中遗传毒性致癌物风险评估方法,为建立我国遗传毒性致癌物风险评估技术体系提供方法学支持。方法 收集目前国际上食品中遗传毒性致癌物风险评估方法的科研文章和指南文件,梳理、对比各种方法的优缺点及其适用范围,研究其中可为我国风险评估借鉴和参考的内容。结果 目前国际上对食品中遗传毒性致癌物进行风险评估的主要方法包括尽可能低作用水平(ALARA),毒理学关注阈值(TTC),低剂量外推和暴露限值(MOE)。尽管ALARA原则容易理解,但是它不能给出任何一个风险程度的指导,所以不能为制定现实的风险管理建议提供可靠的依据。在致癌剂量-反应关系数据缺乏或不足的情况下,若符合毒理学关注阈值适用范围,可以采用毒理学关注阈值的方法进行筛选评估。当来自动物试验的致癌数据可用时,可以采用暴露限值法,也可采用低剂量外推的方法,但推荐优先采用暴露限值法。结论 我国应在充分参与国际遗传毒性物质风险评估相关工作的基础上,深入开展遗传毒性物质基础研究,尽快建立遗传毒性物质风险评估技术体系。

    Abstract:

    Objective To investigate the current risk assessment approaches on genotoxic carcinogens in food, so as to provide methodology support for the establishment of genotoxic carcinogens risk assessment system in China. Methods The current reviews and guidelines for risk assessment approaches on genotoxic carcinogens in foods were collected and the advantages and disadvantages as well as the applicability of different methods were analyzed and compared, the content that could be used or referred for risk assessment in China were investigated. Results Currently, risk assessment approaches for genotoxic carcinogens include as low as reasonably achievable (ALARA), threshold of toxicological concern (TTC), low dose extrapolation of data from rodent carcinogenicity bioassays, and margin of exposure (MOE). Although ALARA principle is easy to understand, it fails to provide any guidance on measurement of risk level and thus is unable to provide reliable evidence to make practical risk management suggestions. TTC approach, within its range of application, can be used for screening assessment when there was lack of dose-response data. When there were sufficient dose-response data from animal studies, both MOE and low dose extrapolation approaches can be applied, yet MOE approach was preferred. Conclusion China should actively participate in international risk assessment for genotoxic carcinogens in food, develop in-depth scientific research into genotoxic carcinogens, and establish technical system for risk assessment of genotoxic carcinogens in food as soon as possible.

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肖潇,隋海霞.食品中遗传毒性致癌物风险评估方法研究[J].中国食品卫生杂志,2018,30(4):425-429.

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  • 收稿日期:2018-03-26
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  • 在线发布日期: 2018-08-16
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