Objective To analyze the arsenic level in main food, and assess the risk of dietary inorganic arsenic exposure of residents in Guangxi. Methods Based on the concentration data of arsenic in 2010-2015 and food consumption data from Guangxi, the dietary exposure of arsenic was estimated by simple distribution model. The margin of exposure (MOE) method was adopted to assess the potential health risks of dietary inorganic arsenic exposure. Results 16 567 samples were analyzed, and the total arsenic detection rate was 42.71% (4 735/11 087), the inorganic arsenic detection rate was 48.07% (2 634/5 480). The average concentration of total arsenic in marine shellfish was the highest, followed by marine fish and mollush. The average concentration of inorganic arsenic was 0.018-0.072 mg/kg, and was the highest in rice. Rice, fresh fruits, eggs, animal offal and its products were calculated directly with the inorganic arsenic detection result. Other foods were calculated with the total arsenic detection result of which were converted to inorganic arsenic. The MOE of mean dietary inorganic arsenic exposure was above 1. However, the MOE values were less than or equal to 1 in the high consumption (P95) of the 18-34 years male group. The main sources of dietary inorganic arsenic was rice, whose contribution rate was much higher than the other food. Conclusion The level of dietary inorganic arsenic exposure in Guangxi residents is safe. However, there might be some potential health risks to the high exposure residents of the 18-34 years male group. Rice was the main food of Guangxi residents, which need further consideration.