A method was developed for the determination of twelve mycotoxins in cereal-based complementary foods for infants and young children by ultra high performance liquid chromatography coupled to mass spectrometry using QuEChERS approach.Methods Sample was extracted with acetonitrile-water-acetic acid (84∶15∶1, V/V). The extracted solution was purified by QuEChERS approach and separated by using Synergi 4μ Fusion-RP C₁₈ (50 mm×2.0 mm,4 μm) chromatographic column, then was determined by ultra high performance liquid chromatography coupled to mass spectrometry. Matrix-matched calibration was used for the quantification.Results Twelve mycotoxins had good linear relationships in the certain correlation ranges with the correlation coefficients all above 0.999. The average recoveries of 12 mycotoxins at three spiked levels ranged from 80.5% to 106.4% with relative standard deviations of 5.3%-9.5%.Conclusion The method is rapid, simple and can be used for the determination of mycotoxins in cereal-based complementary foods for infants and young children.