To find out the trend and epidemiological distribution of the wild mushroom poisoning, so as to provide scientific basis for disease control and prevention, accounting for 57.9% (868/1 498), 25.1% (3 789/15 093) and 57.3% (126/220) of the total numbers.Methods Analyze the data from foodborne disease outbreak reporting system during 2011-2015 in Yunnan Province. Results A total of 868 events, 3 789 cases and 126 deaths of wild mushroom poisoning were recorded by the national foodborne disease outbreak reporting system during 2011-2015 in Yunnan Province. The largest numbers of poisoning events, cases and deaths were reported in 2015, accounting for 43.0% (373/868), 41.4% (1 570/3 789) and 26.2% (33/126) of the total numbers. Most of the wild mushroom poisonings was reported during June-August, accounting for 87.8% (762/868), 86.1% (3 262/3 789) and 87.3% (110/126) of the total numbers. The highest number of wild mushroom poisoning events, cases and deaths was occurred in rural area and households, accounting for 92.1% (799/868), 86.0% (3 258/3 789) and 93.6% (118/126) of the total numbers. Eating by mistake and inappropriate processing were the main course of poisoning events. 53.6% (465/868) events, 54.7% (2 074/3 789) cases and 82.5% (104/126) deaths happened due to eating by mistake. 45.3% (393/868) events, 44.4% (1 681/3 789) cases and 16.7% (21/126) deaths caused by inappropriate processing.Conclusion Wild mushroom poisoning is a serious public health concern in Yunnan Province, and appropriate countermeasures should be taken. The effective measures includes further research and health education.