To investigate the influence of Momordica charantia extract (MCE) on the immune function of BALB/c mice. MethodsA total of 200 female BALB/c mice were randomly divided into negative control group (distilled water), positive control group (cyclophosphamide) and three dosage group (1.11,3.33,0.00 g/kg BW), and the mice were administered intragastrically for 30 days, the effects of MCE on humoral immunity, cellular immunity and nonspecific immunity of BALB/c mice were observed. ResultsThe IgA levels of the middle and high-dose group of MCE compared with the negative control group were significantly higher (P<0.05), the IgG levels of the low dose group were significantly higher than the control group (P<0.05), andthe IL-6, IL-4 levels of the low dose group was significantly higher (P<0.05) compared with the negative control group. Other indicators compared with the negative control group was not statistically significant (P＞0.05).ConclusionUnder the dosage in this study, MCE had some regulatory effects on immune function of BALB/c mice, especially for humoral immunity and cellular immunity. However, there was no significant effects on non-specific immune.