Application of multiple-locus variable number tandem repeat analysis in bacterial molecular typing
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摘要:
多位点可变数量串联重复序列分析(multiple-locus variable number tandem repeat analysis,MLVA)是通过基因组中可变数量串联重复序列(variable number tandem repeat,VNTR)的特征来实现分型的分子分型技术,其特征是简单、快速、通量高、分辨力强,目前已广泛用于多种细菌分子分型。本文就MLVA技术的原理、在细菌分子分型中的应用及与其他分型方法的比较进行综述。
Abstract:
Multiple-locus variable number tandem repeat analysis (MLVA) is a molecular subtyping technique characterized by the trait of variable number tandem repeat (VNTR). This method is simple and rapid with high-throughput and great capability to distinguish different strains, and has been widely used in molecular typing of a variety of bacteria. The principle, application and the comparison of MLVA with other approaches in bacterial molecular typing were reviewed.
