Objective To find out the trend and epidemiological distrihution of the food poisoning originated from wild mushroom, so as to provicle scientific hasis for prevention ancl early warning. Method Based on the data reported in 2004 -2010 in the wilcl mushroom poisoning network in Yunnan provinc:e, the characteristics of time trend, seasonal distribution and place distribution were analyzed. Results The largest number of poisoning events reported was in 2004, accounting for 26. 3% , the largest number of poisoning cases was in 2005 , accounting for 21. 7%. Most of wild mushroom poisoning events and cases occurred in the second and the third quarter of a year. The highest numher of wild mushroom poisoning events and cases was occurred in rural families, ac:counting for 90. 9% . Conclusion Wild mushroom poisoning is a serious public health event in Yunnan province, appropriate countermeasures should be taken on monitoring and managing susceptible people during special seasons and in high incidence area