Objective To understand the serotypes and the sensitivities of foodborne Salmon,ella to antibiotic in Shandong province from 2003 t0 2010, and to provide a basis for policy making on the rational use of drugs in clinical ancl veterinary medicine. Methods The identification of Salmon,ella strains and serotypes was based on GB/T 4789-2008. The antiruicrobial susceptibility of the isolated strains was determined and judged by the mini broth dilution technique rec:ommended by the Clinical and Laboratory Standards Institute ( CLSI). Results The serotypes of 120 Salmon,ella strains which had been identified in Shandong were belonged t0 5 groups (8 subgroups) and 24 serotypes. S. Enteritidis and S. Derby were the ruost common strains; and ,_S. Chwarzengrund, S. Wien, S. Blegdam, S. Muenster and S. Ughelli were detected in Shandong province for the first time. The degree of resistance of 126 Salmonella strains t0 14 antibiotics was different with the highest resistance to naliclixic acid (61. 900/o ) , and followed by tetracycline (33. 33% ) , ampicillin (31. 75% ) and sulfadiazine ( 26. 19% ). The most sensitive antibiotic is cefepime (5. 37% ) , following by amikacin (9. 52% ) and c:iprofloxacin ( 10. 32% ) . Conclusion The situation on the resistance of foodborne Salmon,ella is serious in Shandong province. It is necessary to strengthen the manageruent of using antibiotics in animal husbandry. Reasonahlesteps should he taken by relevant departments from the source of food chain on animal food production to ensure food safety.