副溶血性弧菌食源性疾病暴发分离株的血清型、核糖型及毒力基因研究
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陈洪友 男 公卫医师 研究方向为致病性弧菌与食源性感染研究 E-mail:hychen@scdc.sh.cn

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R378.3

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“十一五”科技重大专项(2008ZX10004-002)


Distribution of serotype, ribotype and virulence gene of Vibrio parahaemolyticus isolated from foodborne disease outbreaks
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    摘要:

    目的 了解目前食源性副溶血性弧菌暴发菌株在上海地区的血清型分布、毒力相关基因的携带情况,及Ribo分型。方法 收集上海市27起食源性副溶血性弧菌暴发事件分离的98株副溶血性弧菌,采用副溶血性弧菌分型血清对所收集的菌株进行血清学分型。利用双重PCR方法扩增tdh、trh两个重要的毒力基因以了解其毒力基因的携带情况。应用Riboprinter系统检测上述菌株的酶切片段杂交多态性。结果引起27起暴发的98株副溶血性弧菌分为11个血清型,5个Ribo型。优势血清型为O3:K6,优势Ribo型为vp-EcorI-002型。全部分离菌株均携带toxR基因,97株携带tdh基因,1株携带trh基因。有多起暴发事件分离到多个血清型的副溶血性弧菌。结论 血清分型和PCR方法检测毒力基因,是副溶血性弧菌暴发事件实验室诊断的有用方法。对于从一起暴发事件中检出的不同血清型的副溶血性弧菌需要确认各菌株与暴发的关系。

    Abstract:

    Objective To find out the distribution of serotype and virulence genes in the Vibrio parahaemolyticus isolated from foodborne disease outbreaks and also the main ribotype of these strains. Methods Ninety eight Vibrio parahaemolyticus strains were isolated from the patients of monitoring points in 27 foodborne disease outbreaks. Diplex-PCR was used to detect tdh and trh gene. Ribotyping was carried out in the Riboprinter system. Results The isolates from 27 outbreak points were distributed in 11 serotypes and 5 ribotypes. The dominant serotype was O3:K6, and the main ribotype was vp-EcorI-002. All strains carried toxR gene, 97 strains carried tdh gene and only 1 strain carried trh gene. Conclusion Most strains in the study were pandemic and toxigenic, and a closer evolution relationship was observed between serotype O3:K6 and serotype O5:K68, O1:K25 and O11:K36.

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陈洪友,陈敏,盛跃颖,屠丽红,张雯霞,张曦,王文静.副溶血性弧菌食源性疾病暴发分离株的血清型、核糖型及毒力基因研究[J].中国食品卫生杂志,2011,23(2):114-117.

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  • 收稿日期:2010-06-28
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