Objective To compare the safety assessment systems on flavorings in China，the United States，European Union and Codex Alimentarius Commission (CAC) ，and to put forward and improve the safety assessment system in China. Method Current and valid regulations and methods on safety assessment of flavorings in CAC，the United States， European Union and China were collected，compared and analyzed. Results The specific agencies for safety assessment of flavorings，methods for evaluating exposure，and procedures for safety assessment in CAC，the United States，European Union and China were not the same. Conclusion Some defects in the safety assessment of flavorings in China were found. It is suggested that the food safety assessment system in China should be perfected further，and a normative toxicological database for flavorings should be set up.