Objective To present the critical strategy and measures with the surveillance on foodborne disease outbreaks in Guangzhou, 2006-2008. Methods Data collected by Foodborne Disease Outbreaks Surveillance and Reporting System （FDOSR） of Guangzhou was analyzed on season, month, pathogen, food, meal place, reason, and so on. Results Total 189 foodborne disease outbreaks were reported, resulting 2678 cases and 6 deaths, with 14.16 illnesses per outbreak, attack rate 13.47%, and fatality rate 0.22%. 166 outbreaks (87.83%) were ascertained of pathogens, with microorganisms of most outbreaks (58.20%) and cases (70.95%), poisonous propagations of largest deaths (66.67%). microorganisms accounted for the highest cases per outbreaks (17.27 cases), while chemical agents of maximum at attack rate (91.83%), poisonous propagations of largest fatality rate (1.86%). Conclusion Efficiency and quality of FDOSR for correct prevention should be improved to reduce the burden of foodborne disease.