The study was to investigate the poisoned situation of accumulation of paralytic shellfish poison of 10 species of shellfish bred in the coastal water of Shenzhen so as to identify the indicator species of shellfish whose content of the poison can indicate the situation of pollution of water by the poison.Using the biological method(AOAC,15th Ed.,1990),the content of the poison in the samples was determined.Chalmys nobilis and Perna viridis were found to have relatively stronger capability of accumulating PSP than other 8 species of shellfish and Chalmys nobilis accumulated more PSP than Perna viridis.The investigation suggests that the indicator species of PSP in Shenzhen are Chalmys nobilis and Perna viridis,and sometimes the content of PSP in them exceeds the safety limit of related standard within a year.This research provides scientific basis for the effective supervision and management.