To investigate the status of food contamination by Salmonellae and the drug resistance of Salmonellae in Shanghai. 303 different food samples were pre-richment, then inoculated on XLD plates after special absorbing with IMS to isolate Salmonellae. The isolated strains were divided into 2 groups based on time of isolation and tested with modified K-B method to test the sensitivity to 28 antibiotics. There were 87 Salmonellae positive results in 303 tests. The positive rate was 28.71%. In the 112 Salmonella serotype, S.derby and S.enteritidis were dominant. The Salmonellae positive rate in meat products was much higher than that in other food products, in which the positive rate was 40.20% (82/204) with 107 different serotypes of Salmonella species ( 107/112, 95.54%). The drug resistant strains of Salmonellae to ciprofloxacin, co-trimoxazole, tobramycin, minocycline, chloramphenicol and streptomycin were obviously changed in the period of 2 years. There were 12 strains of multiple drug resistance, which resisted more than 10 different antibiotics(12/112,10.71%), and 4 strains resisted cefoperazone. Using IMS method isolate Salmonellae from foods samples has better result than the traditional method. It provides a new methodology for surveillance of foods. The increase of ciprofloxacin resistant strains and multiple drug resistant strains warn us that the importance of emphasizing the surveillance of foodborne Salmonellae-resistanted.