In order to prevent food poisoning evoked by ciguatoxin, the sources, chemical structure, properties, poisoning symptoms and the hazard to humans of ciguatoxin were summarized. The measures to guard against ciguatoxin were put forward: reducing intake of coral fish, taking only a little edible coral fish in a meal; don't eat the toxin-accumulated head, liver, gonad, intestines and spawns of the fish; don't drink wine or eat nuts with the fish. The symptoms will be more serious in case of poisoning. Those who have been poisoned should refrain from coral fish because they were apt to be poisoned again. The future research objects about ciguatoxin will mainly be focused on the poisoning mechanism, preparation methods, measuring methods, establishing the precaution system and the antagonistic agents of ciguatoxin.