The issue of food contamination by hormone and antibiotic residues has aroused great attention by both the governments and consumers worldwide. Following the summary of the causes, mechanisms and health hazards occurred by food contamination of hormone and antibiotic residues, the article focuses on the comparison of the regulations and residue limit standards among Codex Alimentarius Commission, European Union, the United States and China, in an effort to follow up the global development in this area. Some recommendations and suggestions on how to strengthen the control of veterinary drug contamination in food are made and appeals for improvement of residue standards and analysis methods are put forward at the end.