Vibrio parahaemolyticus （V. parahaemolyticus） is a significant foodborne pathogen worldwide， primarily transmitted through the consumption of seafood. It can cause both sporadic cases of acute gastroenteritis and outbreaks of foodborne illness. Severe infections may require antibiotic treatment. In recent years， the bacterium has developed varying degrees of antibiotic resistance， largely due to factors such as waste discharge from antibiotic production， improper practices in aquaculture， and the misuse of antibiotics in clinical settings. This article reviews the current status of antibiotic resistance in V. parahaemolyticus both domestically and internationally. It explores key resistance mechanisms， including biofilm formation， efflux pumps on the cell membrane， modification of drug targets， resistance genes， and plasmid-mediated resistance. Finally， it proposes surveillance and control strategies to address bacterial resistance， laying a solid foundation for future research on antibiotic resistance in V. parahaemolyticus