Fluorine is an element widely distributed in the environment， an essential trace element for human body， and also considered as a common environmental pollutant. In recent years， many studies have shown that fluoride exerts male reproductive toxicity， which is characterized by abnormal testicular and epididymis structure， decreased sperm quality， abnormal secretion of reproductive hormones， and weakened antioxidant enzyme activity in testis. In this paper， the toxicity of fluoride exposure to male reproductive system and related regulatory mechanisms are reviewed， so as to provide evidence for the prevention and treatment of fluoride-induced male reproductive damage.