Dendrobium Huoshanense is a local characteristic product in Anhui province with a long history of use. Presently， it exhibits promising prospects as a food and medicinal ingredient， attracting significant attention in the realm of functional research. Simultaneously， the safety assessment of Dendrobium Huoshanense and its products is increasingly gaining recognition. This paper reviews recent studies on the physicochemical properties of Dendrobium Huoshanense and the evaluation of safety for related products and provides a detailed summary and explanation of the functional effects of Huoshan Dendrobium， including immune regulation， antioxidant activity， regulation of blood glucose and blood lipids， anti-inflammatory， anti-tumor， and liver protection. The synthesis of safety and functional research findings on Dendrobium Huoshanense serves as a valuable reference for further exploration of its potential in promoting health and medicinal applications.