Objective To investigate the contamination status， serotype， drug resistance and molecular typing characteristics of Salmonella in retail food in Henan province in 2021.Methods According to the Manual for National Food Safety Risk Monitoring （2021）， retail food was collected from 36 monitoring sites in Henan， Salmonella were tested.Results A total of 2 074 food samples were collected from 36 monitoring sites， with a total positive rate of 1.40% （29/2 074）. The highest detection rate of Salmonella was obtained from meat and meat products （6.21%， 20/322）. Contamination of Salmonella was the highest in farmers’ markets （2.61%， 11/421）. All Salmonella were detected in bulk food and none in prepackaged food. The detection rate in summer and autumn （1.52%， 26/1 714） was higher than that in winter and spring （0.83%， 3/360）， but the difference between the two groups was not statistically significant （χ²=1.008，P>0.05）. The 30 Salmonella isolates were serotyped into 20 distinct serovars and Group B was the most prevalent （43.33%， 13/30）. The highest proportion serotype were Salmonella Agona 10.00% （3/30） and Salmonella Delpy 10.00% （3/30）. 30 strains of Salmonella produced a total of 29 PFGE band types， the similarity was within 49.5%~100.0%. There were only two strains with 100% similar PFGE band pattern.Conclusion The contamination rate of Salmonella in food in Henan province is high， and the drug resistance is relatively serious. There is a large proportion of multiple drug resistance， but there is no obvious dominant drug resistance spectrum. The serotypes of Salmonellas were polymorphic and there was no obvious dominant serotype. The PFGE types showed diversity， and there was no obvious dominant type， indicating that foodborne Salmonella in He’nan Province has a highly sporadic epidemic characteristics.