Objective To analyze the serotype distribution， drug resistance and molecular typing of non-typhoidal Salmonella （NTS） strains in pork sold in Zaozhuang area.Methods NTS strains were serotyped by slide agglutination method. The broth microdilution method was performed to determine the resistance of NTS to 14 antibiotics. Pulsed field gel electrophoresis （PFGE） was applied for molecular typing， and the strain clustering was analyzed by BioNumerics 7.6 software.Results Thirty strains of NTS were divided into 15 serotypes， and the main serotypes were Salmonella rissen （26.67%， 8/30） and Salmonella derby （16.67%， 5/30）. The resistance rate of NTS strains to tetracycline was 80.00%， ampicillin was 76.67%， compound sulfamethoxazole was 63.33%， and the multi-drug resistance rate was 66.67%. There were 46.67% of the strains were resistant to four antibiotics （ampicillin， tetracycline， chloramphenicol and compound sulfamethoxazole）. The PFGE bands were polymorphic without obvious regional aggregation， and the most concentrated were those of S. rissen.Conclusion The NTS strains in the pork sold in Zaozhuang area are mainly S. rissen and S. derby. The drug resistance rates to tetracycline， ampicillin and compound sulfa are high with severe multi-drug resistance. The molecular typing map shows polymorphism.