Objective To understand the antimicrobial resistance and the mobile colistin resistance gene mcr carrying status of Salmonella isolates recovered from foods in mainland China in 2022. Methods Broth microdilution method was used for testing the antimicrobial susceptibility of 575 Salmonella isolates against 17 antimicrobial compounds which belong to 11 categories, and mcr genes were detected by PCR for all tested isolates, followed by whole genome sequencing and bioinformatics analysis in terms of the mcr gene PCR positive isolates. Results The resistant strains accounted for 84.70% (487/575) of the 575 Salmonella isolates and the resistance rate of the tested strains to nalidixic acid was the highest (58.61%, 337/575). We found one Salmonella strain resistant to imipenem and another one to tigecycline. The rate of multi-drug resistance of all isolates was 61.39% (353/575), and some isolates could be concurrent resistant to as much as 10 classes of antimicrobials. There were 147 kinds of antimicrobial resistance spectrums, and the dominant resistance spectrum was SAM-CT-AMP-NAL, accounting for 28.57% (42/147). The antimicrobial resistance rates of Salmonella from different sample sources were significant statistically, with the highest resistance rate (95.51%, 85/89) of Salmonella isolates from frozen raw chickens. Salmonella isolates recovered from both Hebei and Heilongjiang province got a 100% resistance rate. Six Salmonella strains recovered from Hubei, Hebei, Anhui, Liaoning and Shandong provinces and harboring mcr-1 gene were detected with a detection rate of 1.04% (6/575), all of them were multi-drug resistant strains. The predominant resistance genes among these mcr-harboring Salmonella isolates were aac (6')-laa, mcr-1.1, fosA3 and so on, and the main plasmid replicon types were IncI2, IncP1 and IncHI2, respectively. Conclusion The Salmonella isolated from foods in mainland China in 2022 got an overall high level of antimicrobial resistance, with serious phenomenon of multi-drug resistance and complex antimicrobial resistance spectrums. In addition, there were also some isolates with multi-drug resistance while carrying mcr gene, which should be given sufficient attention.