Objective To provide a scientific basis for the prevention and control of foodborne diseases in Chenzhou， the etiological characteristics and epidemiological patterns of foodborne diseases were analyzed.Methods The Case information and stool and anal swab samples were collected from two sentinel hospitals in Chenzhou in 2017 and 2019. According to the methods described in “National Manual of Foodborne Disease Surveillance”， the samples were tested for pathogens， pathogen typing， and drug sensitivity.Results A total of 825 samples of diarrhea cases were collected， and the total detection rate of pathogens was 30.18% （249/825）， including 16.24% （134/825） Salmonella， 11.76% （97/825） Norovirus， 3.52% （29/825） diarrheal Escherichia coli， 0.73% （6/825） Vibrio parahaemolyticus， and 0.12% （1/825） Shigella. Bacterial detection rates were higher in the second and third quarters than in other quarters， and viral detection rates were higher in the first and fourth quarters than in other quarters. The highest pathogen detection rate was 40.79% （31/76） in the 2-6-year-old group. Milk and dairy products， grains and their products， and fruits and their products were suspected foods. The highest detection rate in Salmonella was in Salmonella enterica subsp.（74.63%， 100/134）， the highest detection rate in diarrheal Escherichia coli was in intestinal adhesion type and enterotoxin type （34.48%， 10/29）， and the norovirus was mainly GII type （85.57%， 83/97）. The highest resistance rate of Salmonella to tetracycline was 88.71% （110/124）， and the multidrug resistance rate of Salmonella was 85.48% （106/124）. The resistance rate of diarrheal Escherichia coli to ampicillin was significant （79.31%， 23/29）， and the multidrug resistance rate of diarrheal Escherichia coli was 62.07% （18/29）.Conclusion The main pathogens of diarrheal cases of foodborne diseases were Salmonella and Norovirus in Chenzhou. Salmonella and diarrheal Escherichia coli are highly resistant to antibiotics. Therefore， it is necessary to conduct targeted food safety supervision， strengthen antibiotic resistance monitoring， and strictly prevent antibiotic abuse.