Objective This paper discusses the development and design of food formulations for special medical purposes to provide a reference for product development and design， registration management， and the clinical use of such products.Methods We summarized and analyzed the formulations of formula food for special medical purposes， determined the important aspects of formula development and design， and identified key points for evaluating registration applications.Results The formulation design of formula food for special medical purposes should be based on standards and regulations. The most important thing is to think the formula design as a whole， clinical use shuold be the leading of the formulation design， and attention should be paid to the registration dossiers.Conclusion Formulation design is the most important aspect in the research and development of formula foods for special medical purposes. Attention should be paid to the scientific， rational， and clinical applications of these foods. The administrative department should improve its standards and regulations to ensure they are widely used in clinical practice.