Objective Analysis of the epidemiological and spatio-temporal clustering of aconite poisoning incidents in China from 2010 to 2020 was performed to provide a reference for the development of precise prevention and control measures and the construction of an early warning system.Methods Collection of reports of aconite poisoning incidents in surveillance data from 2010 to 2020 with descriptive analysis and spatio-temporal scan analysis was performed.Results From 2010 to 2020， a total of 380 outbreaks of aconite poisoning with 1 889 illnesses and 75 deaths were reported in China， with a case fatality rate of 3.97% （75/1 889）. The highest number of outbreaks occurred from October to December with 787 cumulative illnesses， accounting for 41.66% （787/1 889） of all cases. More than 86.84% （330/380） of the outbreaks occurred in Yunnan Province and households accounted for 90.26% （343/380） of all outbreak locations. Improper processing resulting in 171 outbreaks， accounting for 45.00% （171/380）. The results of the spatio-temporal scan showed a total of five agglomerative regions， including a category one agglomeration centered in Kunming， Yunnan Province， with an agglomeration period from June 2015 to November 2020， as well as four second-class aggregation areas， including 20 municipalities.Conclusion We should focus on prevention and control in areas with clusters of aconite poisoning， and publicize and popularize high-risk consumption methods to raise awareness on protection and reduce the occurrence of poisoning incidents before the arrival of the high months.