Objective This study aimed to investigate the molecular types and antimicrobial resistance of Vibrio parahaemolyticus isolated from food contamination risk monitoring in Quanzhou City from 2017 to 2021.Methods Vibrio parahaemolyticus was isolated and identified in food samples from various counties. The virulence genes （tdh， trh， and tlh） were detected by fluorescence quantitative PCR and the micro broth dilution method was used for drug-resistance analysis. The molecular typing was analyzed using the pulsed-field gel electrophoresis （PFGE） method. Bionumeries 6.6 software was used to analyze the similarity between strains.Results A total of 65 Vibrio parahaemolyticus strains were isolated from 210 specimens. The drug susceptibility results showed that 65 strains of Vibrio parahaemolyticus showed eight kinds of drug resistance spectra. The resistance rate to polymyxin E was the highest（27.70%，18/65）. All the strains were not resistant to meropenem， ciprofloxacin， ceftazidime/avibactam， tigecycline， azithromycin， nalidixic acid， streptomycin， cotrimoxazole， and amikacin. The 65 strains were divided into 63 PFGE patterns. The similarity between each pattern was 34.67%~100%.Conclusion Vibrio parahaemolyticus exists in food in Quanzhou City. The isolated Vibrio parahaemolyticus have high sensitivity to a variety of antibiotics， the distribution of the strains is polymorphic， and the relationships between them were scattered and distant.