Objective To provide a scientific basis for formulating prevention and control strategies， the epidemic characteristics of mushroom poisoning in Guizhou Province from 2011 to 2021 were analyzed.Methods A descriptive analysis of mushroom poisoning incidents reported to the surveillance system of foodborne disease outbreaks was conducted in the Guizhou Province from 2011 to 2021.Results A total of 1 527 cases of mushroom poisoning were reported in Guizhou province from 2011 to 2021， including 5 312 cases and 95 deaths， with a fatality rate of 1.79%. The largest number of reports was published in 2020. A high incidence was observed in the second and third quarters. The poisoning place mainly occurred in the family. Fifty-five deaths incidents were reported.Conclusion Mushroom poisoning is one of the most reported and fatal foodborne diseases in Guizhou Province， with the highest incidence in rural families. Effective publicity and education should be provided for rural families to reduce mushroom poisoning incidences in Guizhou Province.